β-Trace Protein Is Not Better than Cystatin C as an Indicator of Reduced Glomerular Filtration Rate
نویسندگان
چکیده
منابع مشابه
Beta-trace protein is not better than cystatin C as an indicator of reduced glomerular filtration rate.
To the Editor: Recent studies suggest that serum cystatin C [reviewed in Refs. (1, 2)] and -trace protein (3, 4) identify reductions in glomerular filtration rate (GFR) better than creatinine does. Woitas et al. (5 ) compared for the first time the diagnostic performance of cystatin C, -trace protein, 2microglobulin, and creatinine in relation to inulin clearance. They noted that we reported a ...
متن کاملSERUM CYSTATIN C AS A NEW MARKER OF GLOMERULAR FILTRATION RATE (GFR)
Cystatin C is a 13 KD basic protein that is a member of the cystatin superfamily of cysteine protease inhibitors. The cystatin C gene seems to be a house keeping gene, which is compatible with a stable production rate of cystatin C by most cells. This protein is freely filtered through the glomerulus and almost completely reabsorbed and catabolized by proximal tubular cells. Because of the...
متن کاملCystatin C as a biomarker for estimating glomerular filtration rate.
PURPOSE OF REVIEW Glomerular filtration rate (GFR) is rarely measured in clinical practice because of the complexity of the measurement. As such, kidney function is typically estimated using validated study equations, which use readily available data including age, sex, race, and serum creatinine as filtration marker. Contemporary research suggests that cystatin C may be an improved alternative...
متن کاملCystatin C: an improved estimator of glomerular filtration rate?
BACKGROUND Glomerular filtration rate (GFR) is routinely assessed by measuring the concentrations of endogenous serum markers such as blood urea nitrogen and serum creatinine (SCr). Although widely used, these endogenous markers are not ideal and do not perform optimally in certain clinical settings. The purpose of this review is to critically review the potential utility of cystatin C (CysC), ...
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PURPOSE Recent studies have reported that loss of bone mass is associated with renal function decline and increased fracture risks in chronic kidney disease (CKD) patients. The aim of this study was to investigate the best estimated glomerular filtration rate (eGFR) equation to detect osteopenia in CKD patients. MATERIALS AND METHODS This was a cross-sectional study, and 780 patients aged 50 ...
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 2001
ISSN: 0009-9147,1530-8561
DOI: 10.1093/clinchem/47.12.2181